Background: Wild mushrooms contribute to the well-being of populations around the world and particularly in sub-Saharan Africa both nutritionally and medicinally. This study is a contribution to the knowledge of wild mushrooms involved in the traditional pharmacopoeia of populations in the forest zone of Côte d'Ivoire.

Materials and methods: Ethnomycological surveys were carried out on a sample of 302 people. Mycological inventories were carried out in the various plant formations encountered and the specimens were collected and described at the macroscopic and microscopic level.

Results: this study shows that populations have a good level of knowledge of therapeutic mushrooms. Eleven species involved in traditional pharmacopoeia have been identified, six of which are mentioned for the first time in West Africa. These species are used to treat 17 conditions and one species of mushroom is hallucinogenic. The methods of use cited by the populations are as follows: spraying and enema, spraying and local application, cooking in sauce and drinking, decoction and drink, crushing fresh carpophore and applying the extract to the eyes and ears.

Conclusion: Tri-phytochemicals must be carried out in order to identify the active ingredients that are involved in the treatment of these conditions.